Ozone kills 99% of bacteria

Ozone is a molecule of fundamental importance in our ecosystem, which has played a crucial role in the history of our planet.

Discovered in the 19th century by the German chemist Christian Friedrich Schönbein, ozone has aroused interest both for its protective role in the earth’s atmosphere and for its multiple applications in the industrial, medical and environmental fields.

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The history of ozone begins about 2.4 billion years ago, with the event known as the "great oxygenation," when photosynthetic cyanobacteria began releasing oxygen into Earth's atmosphere. This increase in atmospheric oxygen has led to the formation of stratospheric ozone, which is essential for the protection of life on Earth from the sun's harmful ultraviolet rays.


  • The name ozone comes from the Greek word “OZEIN” which means “smell”.
  • Christian Friedrich Shöbein in (1840) discovered ozone and is considered the Father of ozone therapy.
  • In the 1857 was created on first ozone generator for therapeutic purposes.
  • In the 1870 there was the first report on the effects of ozone used therapeutically to purify the blood.
  • There is evidence of the use of ozone as a disinfectant as early as 1881 on the treatment of diphtheria.
  • In the 1885, the Florida Medical Association has published a book entitled Ozone written by Dr. Charles J. Kenworth, specifying the use of ozone for therapeutic purposes.
  • In the 1896, Nikola Tesla patented his first ozone generator for medical use.
  • The dentist Fisch used ozone in dentistry even before 1932 It is in the 1950 he used ozonated water for therapeutic purposes.
  • In the 1971 the International Ozone Institute (IOI), commonly known today as International Ozone Association (IOA).
  • After 150 years of studies and experiments, today the ozone therapy it is a modality of medical treatment recognized in the majority of the nations of the world.


The industrial applications of ozone have developed very rapidly, particularly in the health sector (hospitals, nursing homes, wellness centers), zootechnics, agriculture, food, military and civil (sanitization of homes, offices and gyms).

Contrary to chlorine and the various chlorine derivatives (harmful to humans), ozone is a gas with a very high oxidation potential, capable of eliminating all types of viruses, fungi, bacteria and spores. This gas can therefore be used for the treatment of water and air, but also for the treatment and prevention of various dental pathologies.

Ozone in dentistry

Ozone is a powerful oxidizing and disinfectant agent, whose applications in dentistry are revolutionizing traditional clinical practices. The use of ozone in dentistry offers a non-invasive and highly effective approach to combat dental infections, promote tissue healing and improve overall oral hygiene


Among the most studied molecules of the twentieth century, ozone was used for the first time in dentistry in 1950. In July 1996, ozone was recognized by the Ministry of Health as “garrison natural for the sterilization of environments”. Since then, thanks to the enormous success of oxygen-ozone therapy, the health applications of ozone have developed very rapidly. Ozone embraces all dental practice, as it is applicable in numerous fields, such as the prevention and treatment of caries, endodontics, oral surgery, periodontology, implantology, the prevention and treatment of surgical infections. Ozone also helps to counteract alveolitis, peri-implantitis and periodontitis. Ozone significantly improves the quality of dental treatment and promotes patient recovery.

Applications in dentistry

  • Caries prevention and treatment
  • Periodontology
  • Endodontics
  • Viral and fungal infections
  • Sinusitis and Temporomandibular joint dysfunction
  • Treatment of bisphophonate-induced lesions
  • whitening
  • Reduction of tooth neck sensitivity
  • Implantology: pre-/post peri-implantitis treatment
  • Immunostimulant action

Ozone therapy does not cause pain

Ozone therapy is a medical treatment that uses ozone, a natural gas with powerful disinfectant and healing properties. One of its main attractions is that it does not cause pain, making it an especially desirable treatment option for many patients.

Our History

Ozone is a biological drug, it leaves no chemical residues, bacterial resistance phenomena are not possible, it is immunostimulant, it has an analgesic and anti-inflammatory effect, it does not cause allergic reactions and it has an antixic effect. By exploiting both the antimicrobial and the metabolic effect, our treatment plans will be far more effective.


I approached ozone quite by accident in 2014 as a patient. But incredulous of the results obtained, I thought that it would have been decisive in my field too. Since then the use of oxygen-ozone therapy has totally upset both my surgical practice and the management of my surgery.
In my clinics both the ambient air and the water of the dental units and rotating instruments are treated, obtaining a great improvement in the predictability of the healings of the surgical operations themselves.

Dr. Piermarco Babando
Ozone therapist dentist

Related clinical studies

Clinical trials represent the cornerstone of evidence-based medicine, the gold standard for determining the efficacy and safety of medical treatments. In the context of dentistry, related clinical studies play a vital role in the constant advancement of the profession, helping to define the best practices for the care and treatment of patients.

Our History

nterv Neuroradiol. 2014 Oct 31
Ozone Therapy in Dentistry
Domb WC. Director, Inland Institute of Aesthetic Dentistry, Upland, CA, USA

J Infect Public Health. 2012 Aug;5(4):269-74
Antimicrobial effects of ozonated water on the sanitization of dental instruments contaminated with E.Coli, S.aureus, C.albicans, or the spores of B. atrophaeus
César J, Sumita TC, Junqueira JC, Jorge AO, do Rego MA. Dental School, Taubaté University, UNITAU, Taubaté, SP, Brazil.

J Oral Maxillofac Surg. 2017 Jan; 75(1): 51.e1-51.e9
Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial
Sivalingam VP, Panneerselvam E, Raja KV, Gopi G.

J Nat Sci Biol Med. 2011 Jul;2(2):151-3.
Ozone therapy in Dentistry: A strategic review
Saini R.

J Periodontal Implant Sci. 2018 Jun 30;48(3):136-151.
The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis
Isler SC, Unsal B, Soysal F, Ozcan G, Peker E, Karaca IR.

Braz Oral Res. 2017 Jan 5;31:e2
Antimicrobial activity of ozone and NaF-cholorhexidine on early childhood caries
Ximenes M, Cardoso M, Astorga F, Arnold R, Pimenta LA, Viera RS.

Open Access Maced J Med Sci. 2018 Feb 14;6(2):389-396
The Effect of Gaseous in Infected Root Canal
Ajeti NN, Pustina-Krasniqi T, Apostolska S.

Eur J Dent. 2016 Jul-Sep;10(3):381-5
Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction
Ahmedi J, Ahmedi E, Sejfija O, Agani Z, Hamiti V.

Open Dent J. 2016 May 11;10:196-206.
Ozone – A Biological Therapy in Dentistry – Reality or Myth?
Naik SV, K R, Kohli S, Zohabhasan S, Bhatia S.

Int J Prev Med. 2018 Apr 11;9:37.
Prevention of Cross-contamination
Savabi O, Nejatidanesh F, Bagheri KP, Karimi L, Savabi G.

Niger J Clin Pract. 2018 Jun;21(6):703-710.
Is Low Level Laser Therapy and Gaseous Ozone Application Effective on Osseintegration of Immediately Loaded Implants?
Karaca IR, Ergun G, Ozturk DN.

J Appl Oral Sci. 2019 Jan 14;27:e20180108
Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial
Seydanur Dengizek E, Serkan D, Abubekir E, Aysun Bay K, Onder O, Arife C.

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